Abstract
The systemic O2 transport (product of arterial O2 content and cardiac output) is decreased after ascent to high altitude. The ability to supply the O2 consumption with a lower systemic O2 transport is most marked in individuals who have resided at high altitude for 2 days or more. The development of the capability to lower the mixed venous O2 content to very low values coincides with the development of a rightward shift in the hemoglobin dissociation curve.
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