Adjusting cardiopulmonary bypass flow or arterial pressure to maintain renal medullary oxygen

Abstract

Cardiopulmonary bypass leads to renal hypoperfusion, resulting in medullary hypoxia and acute kidney injury. In instrumented sheep subjected to cardiopulmonary bypass, Lankadeva etal. found that medullary perfusion and tissue oxygen tension (PO2) was maintained at low-dose metaraminol, an α1-adrenoceptor agonist, because low-dose metaraminol increased perfusion pressure without affecting renal vascular resistance. Lankadeva etal. developed a fiber-optic catheter to measure bladder urine PO2. Urine PO2 tracks medullary PO2, and low urine PO2 predicts acute kidney injury. Adjusting cardiopulmonary bypass to maintain urine PO2 may help avoid acute kidney injury.