Abstract
Siris Samuel G., Paul C. Bermanzohn, Susan E. Mason, Arthur Rifkin, and Jose M.J. Alvir: Adjunctive Imipramine for Dysphoric Schizophrenic Patients with Past Histories of Cannabis Abuse. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1992, 16(4) :539–547. 1. 1. Twenty-one schizophrenic or schizoaffective patients with histories of cannabis abuse and operationally-defined syndromes of post-psychotic depression completed a double-blind trial of adjunctive imipramine added to their on-going medication regimen of fluphenazine decanoate and benztropine. 2. 2. The imipramine-treated patients had superior global outcome. 3. 3. Subscales suggested that specific improvement occurred in imipramine-treated patients in the domain of depression-like features. 4. 4. Psychotic symptomatology was not found to be exacerbated by the imipramine.
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