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Abstract
To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease. A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease. A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%. Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.
Highlights
Crohn’s disease (CD) is a chronic inflammatory condition resulting from aberrant immune system activation
The purpose of this study was to evaluate the adjunctive effect of hyperbaric oxygen therapy (HBOT) in a group of patients with of pharmaco-refractory perineal Crohn’s disease (PCD), enterocutaneous fistulas (ECF) and pyoderma gangrenosum (PG)
A total of 29 patients with pharmacorefractory CD associated with ECF, PCD or PG were selected to HBOT, from 2008 to 2015
Summary
Crohn’s disease (CD) is a chronic inflammatory condition resulting from aberrant immune system activation. The disease primarily affects the gastrointestinal system but other organs may be involved[1]. Clinical manifestations are heterogeneous and may vary from mild cases (abdominal pain, changes in bowel habit and weight loss) to serious complications such as acute abdomen, perineal sepsis, fistulizing disease and colorectal cancer. The course of the disease is usually relapsing but some individuals may experience continuous inflammation[2]. Since CD cannot be cured, most treatment options aim the induction and maintenance of remission by controlling inflammation. Surgery is usually recommended for non-responsive or complicated cases[3]
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