Adjunctive benefit of a xenogenic collagen matrix associated with coronally advanced flap for the treatment of multiple gingival recessions: A superiority, assessor‐blind, randomized clinical trial

Abstract

To evaluate the superiority of coronally advanced flaps (CAFs) when used in combination with a xenogeneic collagen matrix (CMX) for root coverage of multiple adjacent gingival recessions. Participants with at least 2 upper adjacent teeth exhibiting gingival recession depth ≥2mm were recruited and randomized to CAF with (test) or without (control) CMX, respectively. Mean and complete root coverage, amount of keratinized tissue (KTw), gingival thickness (GThick) and patient-reported outcomes (PROMs) were recorded at baseline, 3, 6 and 12months. Twenty-four patients providing 61 gingival recessions were analysed. After 1year, gingival recession depth decreased from 2.3±0.7 to 0.3±0.4mm in the CAF+CMX group (2.0±0.8mm meanRC) and from 2.6±1.0 to 0.6±0.3mm in the control group (2.0±1.1mm meanRC). No difference was observed between the two groups (p=0.2023). Nineteen (63%) of the test and 16 (52%) of control defects showed complete root coverage (p=0.4919). GThick greatly increased in the test group (0.5mm; 0.2-0.8mm, 95% CI; p=0.0057). No difference between the two groups was observed for KTw (p=0.5668) and PROMs. At 1year, CAF+CMX provided similar root coverage to CAF alone, but a significant increase in gingival thickness.