Adiposity may differently affect bone mass in black, brown and white post‐menopausal women (257.6)

Abstract

We evaluated bone mass adequacy and its association with waist and hip circumferences in Brazilian post‐menopausal women stratified by self‐reported skin color. Participants (n=161, mean age 57y) were part of a university staff cohort at Rio de Janeiro (the Pró‐Saúde study). Bone mineral content (BMC) and density (BMD) of total body (TB), lumbar spine (L1‐L4), total hip (TH) and femoral neck (FN) were assessed by DXA. Waist and hip circumferences were measured using standard methods. Differences between skin color groups (black, n=48; brown, n=47 and white, n=66) were evaluated by one‐way ANOVA. Associations between bone parameters and waist or hip circumferences were investigated by Pearson´s and by partial correlation. Prevalence of osteopenia and osteoporosis were 38% and 3%, respectively. TB, TH and FN BMD T‐scores were higher in black compared to white women (P<0.05). Waist and hip circumferences correlated positively with BMC, BMD and BMD T‐score at all bone sites in all skin color groups (r蠅0.29; P<0.05). After adjustment for weight and post‐menopausal period, associations between bone parameters and waist and/or hip circumferences were not significant or, in the case of white women, became negative (r蠄‐0.29; P<0.05) for TB and TH BMC, BMD and BMD T‐scores. Our results indicate higher bone mass in blacks compared to brown and white post‐menopausal women and suggest that waist and hip adiposity may be detrimental to bone mass, especially in white women.Grant Funding Source: Supported by CAPES, FAPERJ (Brazil)