Abstract
BackgroundThis cross-sectional study aimed to evaluating the association between body adiposity markers and high-risk of coronary heart disease (CHD) in patients with type 2 diabetes.MethodsRecent adiposity markers [waist-to-height ratio, conicity index (C-index) and body adiposity index] and traditional markers [BMI, waist circumference and waist-to-hip ratio (WHR)] were measured. The 10-year risk of fatal CHD was estimated according to UKPDS risk engine scores. Patients were divided into high (CHD risk ≥20%; n = 99) or low-moderate (CHD risk <20%; n = 321) risk groups. Multiple logistic regression models were performed to analyze associations between CHD risk (outcome) and adiposity markers.ResultsA total of 420 patients with type 2 diabetes (61.9 ± 9.5 years; 53.5% females; HbA1c 7.6 ± 1.6%) were evaluated. The high risk group had greater proportions of elevated C-index and BMI values than patients with low-moderate risk. No between-group differences in other adiposity markers were observed. In multiple logistic regression models, only C-index values ≥1.35 were associated with CHD risk >20% (OR = 1.69; 95% CI 1.03-2.78; P = 0.039) after adjusting for confounders (sedentary lifestyle, diabetic nephropathy, serum creatinine, and diabetes duration). The association between WHR and CHD risk did not hold in this sample.ConclusionsThe C-index was the body adiposity marker best associated with high risk of fatal CHD in these patients with type 2 diabetes.
Highlights
This cross-sectional study aimed to evaluating the association between body adiposity markers and high-risk of coronary heart disease (CHD) in patients with type 2 diabetes
Body Mass Index (BMI) is the main predictor used to quantify body mass related to height, whereas waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR), and the conicity index (C-index) are markers of central body fat accumulation, and the body adiposity index (BAI) is a predictor of whole body adiposity [9]
Statistical analyses Considering that this study aimed to evaluate the association between body adiposity markers and high risk of CHD, patients were divided into high-risk (CHD risk ≥20%; n = 99) or low-moderate risk (CHD risk
Summary
This cross-sectional study aimed to evaluating the association between body adiposity markers and high-risk of coronary heart disease (CHD) in patients with type 2 diabetes. Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes [1,2] In these patients, the risk of death from vascular causes is 2.32 times higher than in persons without diabetes [3], and diabetes was once considered a coronary heart disease (CHD) risk equivalent [2]. The risk of death from vascular causes is 2.32 times higher than in persons without diabetes [3], and diabetes was once considered a coronary heart disease (CHD) risk equivalent [2] This concept was reinforced by a seminal population-based cohort study conducted in Finland in the late 1990s [4], which study suggested that the risk of coronary events of diabetic patients without previous myocardial infarction was similar to that of nondiabetic patients with a history of myocardial infarction. BMI is the main predictor used to quantify body mass related to height, whereas waist circumference (WC), waist-hip ratio (WHR), waist-height ratio (WHtR), and the conicity index (C-index) are markers of central body fat accumulation, and the body adiposity index (BAI) is a predictor of whole body adiposity [9]
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