Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults: The MESA Cohort Study

Abstract

Obesity is associated with restrictive ventilatory defects and a faster rate of decline in FVC. This association is not exclusively mediated by mechanical factors and may reflect direct pulmonary injury by adipose-derived mediators. Is adipose tissue involved in the pathogenesis of interstitial lung disease (ILD)? We evaluated the association of CT measures of pericardial, abdominal visceral, and abdominal subcutaneous adipose tissue with high-attenuation areas (HAAs) and interstitial lung abnormalities (ILAs) in a large multicenter cohort study of community-dwelling adults, using multivariable-adjusted models. We secondarily evaluated the association of adipose depot size with FVC and biomarkers of obesity and inflammation. In fully adjusted models, every doubling in pericardial adipose tissue volume was associated with a 63.4-unit increase in HAA (95%CI, 55.5-71.3), 20%increased odds of ILA (95%CI, -2%to 50%), and a 5.5%decrease in percent predicted FVC (95%CI, -6.8%to -4.3%). IL-6 levels accounted for 8%of the association between pericardial adipose tissue and HAA. Every doubling in visceral adipose tissue area was associated with a 41.5-unit increase in HAA (95%CI, 28.3-54.7), 30%increased odds of ILA (95%CI, -10%to 80%), and a 5.4%decrease in percent predicted FVC (95%CI, -6.6%to -4.3%). IL-6 and leptin accounted for 17%and 18%, respectively, of the association between visceral adipose tissue and HAA. Greater amounts of pericardial and abdominal visceral adipose tissue were associated with CT measures of early lung injury and lower FVC in a cohort of community-dwelling adults. Adipose tissue may represent a modifiable risk factor for ILD.