Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population.

Jun Zhang,Peng Xu,Siyuan Li,Yulei Ding,Huan Lu,Zongzhi Liu,Wenjing Xu,Jun Li,Jianxin Xie,Na An,Li Yang,Tingting Wang,Yan Wang,Zhiwei Zhang

doi:10.1155/2015/905042

Abstract

Our results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood glucose, and fructosamine in Uygur male subjects were lower than those in Kazak male subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels of TBX1 and TCF21 were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P < 0.01). The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P < 0.01). In conclusion, T2DM in Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.

Highlights

Diabetes mellitus (DM), known as diabetes, is a chronic and heterogeneous metabolic disorder that affects millions of people worldwide
The previous study showed that the increasing global prevalence of type 2 diabetes mellitus (T2DM) is associated with the rising obesity rates [1], and the obesity is a key factor in the development of T2DM [2]
The systolic blood pressure values in Uygur male and female subjects were significantly greater than those in Kazak male and female subjects, and blood glucose values were significantly greater in Uygur female subjects than in Kazak female subjects

Summary

Introduction

Diabetes mellitus (DM), known as diabetes, is a chronic and heterogeneous metabolic disorder that affects millions of people worldwide. The previous study showed that the increasing global prevalence of type 2 diabetes mellitus (T2DM) is associated with the rising obesity rates [1], and the obesity is a key factor in the development of T2DM [2]. The Uygur subjects had significantly greater waist-hip ratio (WHR) than the Kazak subjects, and the Uygur subjects had increased fat distribution in the abdominal viscera, whereas the Kazak subjects had more subcutaneous fat [3]. Ibrahim reported that abdominal obesity imparts a greater risk of developing diabetes and future cardiovascular events than peripheral or gluteofemoral obesity, and visceral adipose tissue has a higher rate of insulin-stimulated glucose uptake compared with subcutaneous obesity [4]. Perrini et al reported that cytokine release profiles were distinct in the subcutaneous and visceral adipose tissue [6]

Methods

Results

Conclusion