Abstract
To analyze the healing effects of stromal vascular fraction (SVF) application compared to wound dressing with 2% silver sulfadiazine in full thickness burn wounds in rats. Animals were divided into two groups: 2% silver sulfadiazine group and SVF group. Both groups received occlusive bandages while the first one was treated with 2% silver sulfadiazine and the latter was treated with injections of SVF prepared from adipose tissue extracted from an animal donor. The animals were accompanied through 3, 7 and 30 days for evaluation of macroscopic, microscopic and morphometric aspects. On day three, a significant increase (p<0.05) of infiltration of polymorphonuclear, fibrin formation and fibroblasts migration in SVF group was observed. On the 7th day the mononuclear infiltrate, angiogenesis, collagen and fibroblasts were significantly increased in the SVF group (p<0.05). At 30 days significantly increased collagen deposition was observed in the SVF group (p<0.05) . Adipose tissue derived stromal vascular fraction injections promotes better wound repair than 2% silver sulfadiazine in the treatment of full thickness burn in rats during the evaluated experimental period.
Highlights
Full thickness burns are characterized by destruction of all skin layers
The destruction of the free nerve endings in the dermis makes these lesions painless, and grafting procedures are often needed to optimize tissue repair that usually evolves with formation of hypertrophic scars, severe fibrosis and tissue adhesion[1]
Considering the need to develop interventions which address the reduction of fibrosis, restrictions in tissue mobility, aesthetic deformities and functional limitations in full thickness burn injuries, this study aimed to compare the microscopic, macroscopic and morphometric effects between the treatments with stromal vascular fraction (SVF) applied intradermally and occlusive bandages with 2% silver sulfadiazine in experimentally induced full thickness burn wounds in rats
Summary
Full thickness burns are characterized by destruction of all skin layers. The global incidence of burns requiring medical intervention in 2004 was about 11 million people. The majority of cases throughout the world are not fatal, fire related burns are among the leading causes of disability in low and middle income countries[2]. The Brazilian Burn Society estimates that millions of burn cases occur every year in Brazil. Two hundred thousand are treated at emergency wards and forty thousand require hospitalization. Estimates presented in a study conducted in the Federal District of Brazil showed a mortality rate of 6.2% among hospitalized burns victims in emergency wards. Among violent causes of death in Brazil burn injuries represent the third most important cause after road accidents and homicides[3]
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