Abstract
BackgroundTo evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D).MethodsIn 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6–6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction.ResultsCompared to NG subjects, those with IFG or nT2D had higher prevalence of FL and elevated VAT. FL was found to be independently associated with IFG and nT2D. Adipo-IR increased the association between FL and IFG [OR: 2.46 (95% I.C.: 1.73–3.49) to 5.42 (3.11–9.41)], whereas low adiponectin levels had a higher effect on the FL and nT2D association [OR: 4.26 (2.18–8.34) to 8.53 (2.96–24.55)].ConclusionFatty liver was independently associated with IFG and nT2D. Our results indicate for the first time, that adipose tissue dysfunction increases these associations.Electronic supplementary materialThe online version of this article (doi:10.1186/s13098-016-0189-6) contains supplementary material, which is available to authorized users.
Highlights
To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fast‐ ing glucose (IFG) or newly diagnosed type 2 diabetes mellitus
visceral adipose tissue (VAT) is a source of excessive release of free fatty acids (FFA) and inflammatory adipokines to the portal vein leading to hepatic fat accumulation, which in turn affects glucose and lipoprotein metabolism and contributes to the inflammatory process [3]
To evaluate the potential effect of adipose tissue dysfunction on the association of FL with Impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D), we assessed the effect of FL alone and the effect of FL plus each one of the adipose tissue function markers (Table 3). These analyses showed that the presence of Adipo-Insulin resistance (IR) had the strongest effect on the association between FL and IFG, followed by low adiponectin levels and elevated FFA
Summary
To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fast‐ ing glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). For many years adipose tissue was considered an organ of energy deposit and thermal insulation. This concept has changed during the last decades, and it is clear that adipose tissue is a complex endocrine organ with high metabolic activity [1]. VAT is a source of excessive release of free fatty acids (FFA) and inflammatory adipokines to the portal vein leading to hepatic fat accumulation, which in turn affects glucose and lipoprotein metabolism and contributes to the inflammatory process [3]. Because Adipo-IR, elevated FFA, and low adiponectin are abnormalities associated with adipose tissue excess, liver injury and related comorbidities, their presence could be considered as a marker of dysfunctional adipose tissue [4, 7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
