Year-end Sale % OFF 
Abstract
Effects of protein malnutrition on adipose tissue development were studied in weanling male Sprague-Dawley rats fed isocaloric diets ad libitum containing either 22% (controls) or 8% (protein-malnourished rats) casein, and in rats pair-fed to the protein-malnourished rats with the 22% casein diet. After 32 days on the diet, protein-malnourished rats were 37% and pair-fed 67% the weight of the controls, while torso length was 37% and 73% of controls, respectively. Food consumption relative to body weight was greatest in protein-malnourished rats. Compared to control rats, the distal epididymal adipocyte number in the protein-malnourished rats was decreased in proportion to the decrease in body size and was more closely related to the protein intake than to the total calories consumed. After 32 days on diet, mean adipocyte number per 2 distal pads was 11.7 x 10(6) in controls and 4.3 x 10(6) in protein-malnourished rats. In pair-fed rats, cell number lagged behind controls at 4 and 11 days, but was normal at 32 days (11.4 x 10(6) cells). The distal epididymal pad adipocyte size and percent lipid were similar in all groups during the first 25 days of dietary treatment. Adipocyte size was increased significantly in controls at day 32 compared to the other two groups. At each time studied through day 25 on diet, epididymal pad weight was related to the adipose cell number rather than the cell size. It is concluded that severe restriction of dietary protein during the postweaning period of growth in rats results in decreased epididymal adipocyte proliferation and/or differentiation concomitant with generalized growth retardation, whereas isocaloric feeding of a diet of normal protein content is associated with only a transient delay in adipose tissue development.
Highlights
Effects of protein malnutrition on adipose tissue development were studied in weanling male SpragueDawley rats fed isocaloric diets ad libitum containing either 22% or 8% casein, and in rats pair-fed to the protein-malnourished rats with the 22% casein diet
Studies relating dietary manipulation to adipose tissue development suggest that dietary protein may play a critical role in the growth of this tissue, as itdoes in other organs [1]
The behavior pattern of the protein-malnourished animals appeared tboe altered after a short time. They were oftenobservedto eatduringthe day, while the control animalsfollowed the usual nocturnalfeedingpattern.Althoughtheprotein-malnourished animals were quieter than controls when undisturbed, they became more excitable during handlingand,after 2-3 weeks onthediet,unsteady gait and athetoid movements of the head and torso were frequently observed
Summary
Effects of protein malnutrition on adipose tissue development were studied in weanling male SpragueDawley rats fed isocaloric diets ad libitum containing either 22% (controls) or 8% (protein-malnourishedrats) casein, and in rats pair-fed to the protein-malnourished rats with the 22% casein diet. It is concluded that severe restriction of dietary protein during thepostweaning period of growth in rats results in decreased epididymal adipocyte proliferation andlor differentiation concomitant with generalized growth retardation, whereas isocaloric feeding of a diet of normal protein content isassociatedwithonly atransient delayin adipose tissue development. Ata slower rate, combined withlipidfillingof preexisting cells,occurs up to 10-14 weeksof age, beyond which the total epididymal adipose cell number becomesstabilized and only changes in size occur [5]. In rats, both the epididymal adipocyte number and size can be altered when nutritional or other stresses are imposed during thepreweaning period of growth. The effect of decreased protein consumption on adipocyte size andnumber hasbeen separated from that of simple caloric restriction
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
