Abstract
Wound healing is one of the most complex physiological regulation mechanisms of the human body. Stem cell technology has had a significant impact on regenerative medicine. Adipose stem cells (ASCs) have many advantages, including their ease of harvesting and high yield, rich content of cell components and cytokines, and strong practicability. They have rapidly become a favored tool in regenerative medicine. Here, we summarize the mechanism and clinical therapeutic potential of ASCs in wound repair.
Highlights
The skin is the largest organ of the body
Wound healing is a highly complex physiological regulation mechanism (Rodrigues et al, 2019) and a sophisticated multicellular process involving the coordination of various cell types and cytokines (Ho Jeong, 2010)
Interactions involving epidermal and dermal cells, extracellular matrix (ECM), cytokines, and growth factors coordinate the entire repair process, which can be roughly divided into three stages: inflammation, new tissue formation, and reconstruction (Heublein et al, 2015; Rodrigues et al, 2019)
Summary
The skin is the largest organ of the body. It is a key structure that protects internal tissues from mechanical damage, microbial infection, ultraviolet radiation, and extreme temperatures (Falanga, 2005; Ren et al, 2019; Rodrigues et al, 2019; Yang et al, 2020). Interactions involving epidermal and dermal cells, extracellular matrix (ECM), cytokines, and growth factors coordinate the entire repair process, which can be roughly divided into three stages: inflammation, new tissue formation, and reconstruction (Heublein et al, 2015; Rodrigues et al, 2019). When new blood vessels are formed, resident fibroblasts proliferate and invade fibrin clots to form contractile granulation tissue and produce collagen (Heng, 2011; Ansell and Izeta, 2015; Morikawa et al, 2019). This is followed by the proliferation of epidermal stem cells to rebuild the epidermis and stem cells from sebaceous glands, sweat glands, and hair follicles to form epidermal attachments
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