Abstract
The role of IR and metabolic disorders has become a crucial topic of study in the pathogenesis of PCOS. Adipose tissue is an important target organ of insulin, and adipose IR plays an important role in the occurrence and development of PCOS. This study seeks to investigate the role of adipose IR in the development of PCOS and to examine its relationship with circulating betatrophin levels in women with PCOS. A cross-sectional analysis of a cohort of women with PCOS and healthy women was performed in this study. Serum betatrophin concentrations were measured by ELISA. Adipose IR was calculated using the product of fasting insulin and FFA concentrations, and the relationship between adipose IR, circulating betatrophin, and other parameters was analyzed. Adipose IR in women with PCOS was significantly higher than that in controls. We found that women with PCOS who have adipose IR (adipose IR ≥ 55) have a higher BMI and higher blood glucose, insulin, PRL, FFA, TG, HOMA-IR, AUCglucose, AUCinsulin, VAIfemale, and BAI levels than PCOS-afflicted women without adipose IR, while M-values, and SHBG and LH levels were lower. In women with PCOS, serum betatrophin levels were significantly increased compared with controls. Adipose IR negatively correlated with M values and positively with circulating betatrophin levels in the study population. After metformin treatment, circulating betatrophin levels and adipose IR in women with PCOS were significantly decreased compared with pretreatment. Adipose IR is associated with betatrophin levels in women with PCOS. The combination of adipose IR and circulating betatrophin measurements may be significant for screening patients with PCOS.
Highlights
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women and affects about 10% of reproductive-aged women [1]
We divided PCOS women into two subgroups based on adipose insulin resistance (IR): Q1, adipose IR < 55 and Q2, adipose IR ≥ 55, which was defined as having adipose IR. e results showed that PCOS women with adipose IR ≥ 55 had higher body mass index (BMI), blood glucose, insulin, Free fatty acid (FFA), TG, HOMA-IR, AUCglucose, AUCinsulin, VAIfemale, and BAI than women with PCOS who had adipose IR < 55, while M values were lower (Table 1, Figure 1(c))
We found that BMI, DBP, fasting blood glucose (FBG), 2 -hour postglucose load blood glucose (2h-BG), FIns, 2 h plasma insulin after glucose overload (2h-Ins), TG, total cholesterol (TC), FFA, HOMA-IR, AUGinsulin, VAIfemale, luteinizing hormone (LH), and free androgen index (FAI) were significantly decreased, whereas M value and sex hormone-binding globulin (SHBG) were markedly increased after treatment, as compared with pretreatment (Table 3)
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women and affects about 10% of reproductive-aged women [1]. Hyperandrogenism, menstrual disorders, and polycystic ovaries are three important characteristics of PCOS [2]. E role of insulin resistance (IR) and metabolic disorders in the pathogenesis of PCOS has been gaining more and more attention [3, 4]. About 70% of women with PCOS have IR and related metabolic disorders [7], which results in hyperinsulinemia and increases the risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) [8, 9]. The role of IR-related cytokines in the pathogenesis of PCOS has attracted much attention [3, 12]
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