Abstract
Despite multiple methods of treatment and a wealth of research in the field of regenerative medicine focusing on cartilage defects, the management of cartilage injuries remains a challenge. A recent study by Van Pham and colleagues proposes a method for preconditioning autologous adipose-derived stem cells. Their study offers evidence about the increased proliferative and chondrogenetic capabilities of platelet-rich plasma-treated adipose-derived stem cells and the increased efficiency of these in treating articular cartilage defects in mice. Even though the method needs further elaboration and the composition of the repair tissue requires investigation, the results are promising for the design of clinically acceptable cell therapies aimed at cartilage regeneration.
Highlights
Despite multiple methods of treatment and a wealth of research in the field of regenerative medicine focusing on cartilage defects, the management of cartilage injuries remains a challenge
Different tissue engineering or cell therapy scenarios have been proposed, raising hope for possible complete structural and functional joint resurfacing in the near future. Bringing such expectancy closer to clinical applicability, a recent study by Van Pham and colleagues [1] reports a method of using adipose-derived stem cells (ADSCs) preconditioned with activated platelet-rich plasma (PRP) as combined cell therapy for the management of post-traumatic articular cartilage defects
The study by Van Pham and colleagues [1] proposes that ADSC chondrogenic potential can be enhanced and vascular endothelial growth factor (VEGF) release can be reduced by supplementing the culture media with PRP
Summary
Despite multiple methods of treatment and a wealth of research in the field of regenerative medicine focusing on cartilage defects, the management of cartilage injuries remains a challenge. * Correspondence: drlluminita@yahoo.com 1Department of Orthopedic Surgery, University Hospital Saint Spiridon, Iasi 700111, Romania 2SBIM Systems Bioinformatics and Modeling, GmbH, Basalt str. Current therapies provide good short-term improvement within acceptable time frames; medium- and long-term improvement in the injured cartilage is still hampered by the occurrence of post-traumatic arthritis.
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