Abstract
Aim: To evaluate the potential capability of adipose-derived stem cellexosomes (ADSC-exos) on rotator cuff repair by mediating the tendon-derived stem cells (TDSCs) and explored the mechanism. Methods: First, we investigated the growth, survivaland migration of TDSCs in the presence of ADSC-exos in vitro. Using a rat rotator cuff injury model to analyze the ability of the ADSC-exos to promote rotator cuff healing in vivo. Results: The hydrogel with ADSC-exos significantly improved the osteogenic and adipogenesis differentiation and enhanced the expression of RUNX2, Sox-9, TNMD, TNCand Scxand the mechanical properties of the articular portion. Conclusion: The ADSC-exos have the potential to promote the rotator cuffrepair by mediating the TDSCs.
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