ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease.

Qiuxia Han,Dong Zhang,Guangyan Cai,Wenjia Geng,Hanyu Zhu

doi:10.1155/2020/5158497

Abstract

Background This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). Methods Relevant studies were identified from digital databases such as Embase, PubMed, Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixed- or random-effects models. Interstudy heterogeneity was examined using the Q test and I2 statistic, and sensitivity analysis was implemented to test the statistical stability of the overall estimates. Begg's funnel plot and Egger's test were applied to inspect potential publication bias among the included studies. Results The overall ORs reflected a positive correlation between the ADIPOQ rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. TT+TG comparisons (OR = 1.51, 95%CI = 1.16 − 1.95; OR = 1.43, 95%CI = 1.11 − 1.85). After stratification analyses by ethnicity and disease type, a similar trend was also revealed in the Caucasian and African subgroups as well as in the type 2 diabetes mellitus (T2DM) subgroup. Conclusion The ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients.

Highlights

In diabetic patients, microvascular lesions and accelerated atherosclerosis tend to trigger complications leading to severe morbidity [1]
Reports show that approximately one-third of diabetic patients will eventually develop diabetic kidney disease (DKD), so it is of great significance to identify risk factors for DKD occurrence [3]
A comprehensive literature search was conducted in electronic databases, including Embase, PubMed, Medline, Cochrane Library, Google Scholar, Wanfang, and Chinese National Knowledge Infrastructure (CNKI), using different combinations of the following keywords: “diabetic kidney disease” or “DKD” or “diabetic nephropathy” or “DN” or “diabetic renal disease” or “DRD” or “diabetic end-stage renal disease” or “diabetic ESRD” or “diabetic renal dysfunction” or “diabetic kidney failure” or “diabetic microalbuminuria” or “diabetic albuminuria” or “diabetic proteinuria” or “diabetic glomerulosclerosis” or “Kimmelstiel-Wilson Syndrome” or “Kimmelstiel-Wilson Disease” or “diabetic complications”, and “adiponectin” or “ADIPOQ”, and “polymorphism” or “variant” or “mutant” or “single nucleotide polymorphism” or “SNP” or “genotype” or “allele”

Summary

Introduction

Microvascular lesions and accelerated atherosclerosis tend to trigger complications leading to severe morbidity [1]. The ethnic disparity in DKD development may be attributed to an important role of genetic factors, and sex has been demonstrated to influence the predisposition of diabetic patients to developing kidney diseases, with males having a relatively higher incidence rate [5]. This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). The ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients

Methods

Results

Conclusion