ADIPOQ +45T>G, +712A>G and +4545C>G variants are associated with dyslipidemia in Chinese pre-eclampsia women

Abstract

The pathogenesis of pre-eclampsia, the most common complication in obstetrics, is unclear. Family based studies have shown that the incidence of pre-eclampsia is related to genetic factors. Lipid profile indicated that pre-eclampsia were also accompanied by dyslipidemia. We would like to evaluate the influence of common polymorphisms of the adipose most abundant gene transcript-1, adiponectin (ADIPOQ) gene on the lipid metabolism, and pre-eclampsia in Chinese Han women of pregnancy. Clinically defined pre-eclampsia patients (n = 221) and healthy pregnant women (n = 271) were recruited. PCR-RFLP was used to genotype ADIPOQ +45T/G, +712A/G, and +4545C/G single-nucleotide polymorphisms (SNPs). Changes in metabolic and clinical data were analyzed according to SNPs and groups. +45TT genotype had a relatively lower ApoA1 level than G-allele carrier in case group (p = 0.002). In the controls, systolic blood pressure (SBP) levels were higher in +712AA genotype group than G-allele carriers’ (p = 0.009), +4545CC were higher than G-allele carriers’ (p = 0.009). No significant association between the ADIPOQ genotype or the alleles and pre-eclampsia had been observed. There is a strong linkage disequilibrium between polymorphic loci +45T>G and +712A>G, +45T>G and +4545T>G, and +712A>G and +4545T>G, respectively. ADIPOQ gene might affect SBP and lipid metabolism of pre-eclampsia, although the three polymorphic sites on ADIPOQ gene are not the major genetic determinants of susceptibility to pre-eclampsia in Chinese women.