Adiponectin, Non-Esterified Fatty Acids and Antiphospholipid Antibodies in Type II Diabetes Mellitus

Mirjana Bećarević,Nada Majkić-Singh,Sandra Singh,Svetlana Ignjatović,Jelena Seferović

doi:10.2478/v10011-012-0009-y

Abstract

Adiponectin, Non-Esterified Fatty Acids and Antiphospholipid Antibodies in Type II Diabetes MellitusThe importance of the association of antiphospholipid antibodies (aPL Abs) with the features of type II diabetes mellitus has not yet been elucidated. The aim of this work was to investigate the association of aPL Abs with adiponectin and non-esterified fatty acids (NEFA) in type II diabetes mellitus patients without micro and/or macrovascular complications, and to analyze the differences between the male and female patients with regard to the abovementioned parameters. Male patients with type II diabetes mellitus showed a positive correlation between NEFA concentrations and anti-oxLDL antibodies (r=0.334, p=0.019). A weak, but statistically significant correlation between adiponectin concentrations and the IgM isotype of anti-annexin A5 antibodies was found in type II diabetes mellitus patients (r=0.285, p=0.011). The presence of a positive correlation between NEFA and anti-oxLDL antibodies might be useful in the detection of patients with premature atherosclerosis in type II diabetes mellitus patients without any micro and/or macrovascular complications among type II diabetes mellitus patients.

Highlights

The existence of a procoagulant state has been found in type II diabetes mellitus patients [1]
In the present study we investigated the association of antiphospholipid antibodies (aPL Abs) with adiponectin and non-esterified fatty acids (NEFA) in a wellformed group of type II diabetes mellitus patients without micro and/or macrovascular complications
Adiponectin concentrations were in a positive correlation with HDL (r=0.423, p=0.000) and apo AI concentrations (r=0.333, p=0.004) and in an inverse correlation with triglyceride concentrations (r=–0.234, p=0.039) and with waist-hip ratio (WHR) (r=– 0.324, p=0.004)

Summary

Introduction

The existence of a procoagulant state has been found in type II diabetes mellitus patients [1]. Antiphospholipid antibodies (aPL) may cause and/or promote thrombosis [2,3,4,5]. Various mechanisms that explain the roles of antiphospholipid antibodies in the pathogenesis of the antiphospholipid syndrome have been. 200 Be}arevi} et al.: Adiponectin, non-esterified fatty acids and antiphospholipid antibodies in type II DM proposed, but the importance of the association of aPL Abs with the features of type II diabetes mellitus has not yet been elucidated. Adiponectin has a role in the relationship between obesity and insulin resistance [7]. Previous reports have suggested that inflammation might be considered as the link between insulin resistance, obesity and diabetes mellitus [8]

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