Adiponectin is associated with lipid profile and insulin sensitivity in French adolescents

Abstract

Aim The favourable relationship of adiponectin with the metabolic profile demonstrated in adults has been less studied in youths. The aim of this study was to examine cross-sectional and longitudinal associations between adiponectin and various metabolic risk factors in 12-year-old adolescents. Methods Subjects were participants in a randomized controlled study to promote physical activity (PA). Cross-sectional associations were assessed at entry in 2002 among 647 PA-exposed and control first-level students (49% male, 11.6 ± 0.6 years of age). Longitudinal analyses involved 288 control students surveyed in 2002 and 2004. Baseline measurements included fasting serum adiponectin and anthropometric indices (body mass, waist size, body fat [BF] by bioimpedance), insulin concentration, homeostasis model assessment (HOMA), high-density lipoprotein (HDL) cholesterol, triglycerides (TG), soluble TNF-α receptor 1 (sTNF-α R1) and high-sensitivity C-reactive protein. Analyses were performed with generalized linear mixed-effects models, taking into account correlations among adolescents in the same school. Results Cross-sectionally, plasma adiponectin was inversely associated with obesity indices, especially waist size ( P < 10 −2), HOMA ( P < 0.03), insulin ( P < 0.04), TG ( P < 10 −2) and sTNF-α R1 ( P < 0.05), and positively related to HDL cholesterol ( P < 10 −4), after adjusting for age, gender, sexual maturity, sports participation and adiposity when relevant. Longitudinally, a higher baseline adiponectin level was associated with a more favourable two-year change in TG ( P < 0.05), even after accounting for baseline TG, and two-year BF and insulin changes. Conclusion The findings of this study suggest a favourable relationship between adiponectin and both metabolic profile and subsequent changes in TG level in young adolescents.