Abstract
Adiponectin is an endogenous bioactive protein secreted mainly by adipocytes, and exists in peripheral blood in three forms, including trimers, hexamers and high-molecular weight multimers. By binding to its receptor and activating downstream signaling pathways, it plays an important role in regulating metabolism and immune balance, inhibiting cell proliferation and inflammatory reaction, and maintaining vascular homeostasis. The immunoregulatory effect of adiponectin has been gradually becoming a focus of researches. Recent studies have indicated that adiponectin is actively involved in the development of immune-mediated skin diseases. With further insights into the immunoregulatory effect of adiponectin, great progress has been made in elucidating the relationship between adiponectin and immune-mediated skin diseases, which will provide new methods and ideas for clinical treatment of immune-mediated skin diseases. This review summarizes the relationship between adiponectin and immune-mediated skin diseases, such as psoriasis, systemic lupus erythematosus, scleroderma and Sjogren's syndrome. Key words: Psoriasis; Lupus erythematosus, systemic; Scleroderma, systemic; Sjogren's syndrome; Adiponectin; Receptors, adiponectin
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