Adipokines vaspin and omentin-1 are up-regulated in large for gestational age infants at term

Abstract

ObjectiveLarge- (LGA) and appropriate-for-gestational age (AGA) infants differ in body fat mass and metabolic/endocrine mechanisms. We aimed to investigate in LGA and AGA infants possible alterations in cord blood levels of insulin and the adipokines vaspin and omentin-1 which are secreted by the adipose tissue and are implicated in insulin resistance/metabolic syndrome. MethodsCord blood vaspin, omentin-1 and insulin levels were prospectively measured in 61 LGA and 36 AGA singleton full-term infants. Of the LGA group 13 infants were born from diabetic and 48 from non-diabetic mothers. ResultsCord blood vaspin and omentin-1 levels were significantly higher in LGA compared with AGA neonates (p=0.021 and b=0.115, SE 0.037, p=0.002, respectively). Umbilical cord omentin-1 levels were significantly decreased in neonates delivered vaginally (b=−0.075, SE 0.031, p=0.016), after controlling for group. Insulin levels increased in proportion to the customized centiles of the infants (b=0.004, SE=0.001, p=0.009). Finally, in the LGA group vaspin levels correlated with omentin-1 serum levels (r=0.318, p=0.013). ConclusionsThe increased levels of vaspin observed in LGA infants compared with AGA ones, possibly represent a defensive mechanism against insulin/glucose dysregulation, commonly seen in the former. In addition, the increased omentin-1 levels in the LGA group could possibly reflect the amount of developing adipose tissue in the early stages of life in this group. Alternatively, these levels could reflect the growth-promoting effect of omentin-1 in the fetus. The inflammation associated with vaginal deliveries may account for the lower cord blood omentin-1 levels in neonates delivered by this mode.