Abstract
We examined 173 overweight patients with bronchial asthma (BA) using ELISA method, identifying leptin, adiponectin and resistin from samples of plasma and sputum. The idea that BA is heterogeneous in relation to adipokines signaling dependant on the variant of BA, severity of disease, sex and age of patients has been advanced. The imbalance of proinflammatory (leptin, resistin) and antiinflammatory (adiponectin) signaling molecules, at the system level, organ level (in sputum) and target cells (mononuclear cells peripheral blood) was revealed. The identification of the phenomenon of presence of adipokines (leptin and resistin) in the sputum is considered as one of mechanisms of adipokines elimination during exacerbation of BA, which allows to extend the understanding nonrespiratory lung function in BA. Refs 15. Figs 5. Tabl. 11.
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