Adipokine Responses To Exercise Repeated On Successive Days In Men With Metabolic Syndrome

Abstract

PURPOSE: To examine the temporal responses of adipokines to repeated exercise bouts in successive days in obese males with metabolic syndrome and their relationship with markers of insulin resistance. METHODS: Volunteers were 11 males (age = 50 ± 8.0 years, BMI = 32.0 ± 4.6 kg/m2, Fat = 29 ± 4.0%, VO2max = 28.9 ± 4.3 ml.kg.-1min-1, SBP = 140 ± 8.6 mmHg, DBP = 92 ± 6.3 mmHg, triglyceride = 267 ± 145.0 mg/dL, HDL-C = 32 ± 5.0 mg/dL, glucose = 99.6 ± 12.8 mg/dL), that performed four exercise sessions walking on a treadmill at 60 to 70% of VO2max and expending 350 kcals of energy on each of four successive days. Blood samples were obtained before each exercise session and obtained again at 24 and 72 hours after the last exercise bout. Total and HMW adiponectin, leptin, NEFA, glucose and insulin were determined after adjusting for plasma volume shifts. We used a multiple 1 x 6 repeated-measures ANOVAs to determine significance. RESULTS: Insulin concentrations decreased 26% with a single bout of exercise and leptin decreased 9% after two exercise sessions and remained lower up to 24 hours following the last exercise session. NEFA, glucose, the HOMA score, adiponectin and HMW adiponectin remained unaltered with exercise. The accumulated effect of multiple bouts of exercise in leptin concentrations were greater than the effect obtained from two exercise bouts but not related to changes in insulin concentrations or the HOMA score. CONCLUSION: Plasma leptin concentrations were transiently reduced in obese men with metabolic syndrome and this reduction was maintained up to 24 hours after exercise. Adiponectin and HMW adiponectin were unaltered by exercise. No further change in adipokines and markers of metabolic health were observed after exercise repeated on successive days.