Adipokine Production in Mice Fed High‐fat Diets Containing Different Types of Dietary Fats

Abstract

The present study compared high‐fat diets containing different types of dietary fats with various levels of linoleic acid (18:2n6, LA) and α‐linolenic acid (18:3n3, ALA) on adipokine production in male C57BL/6 mice. Three‐week old mice were fed AIN93G diet (15% of energy from corn oil, control) or a high‐fat diet with 45% of energy from corn oil (ALA deficient, high LA), soybean oil (ALA adequate, high LA), high‐oleic sunflower oil (ALA adequate, low LA), flaxseed oil (ALA adequate, LA adequate) or fish oil (high ALA, eicosapentaenoic acid (20:5n‐3, EPA) and docosahexaenoic acid (22:6n‐3, DHA), low LA) for 11 weeks. High‐fat diets, regardless of types of oils, increased body weight (P < 0.05) and body fat mass (P < 0.05) compared to the AIN93G‐fed controls; there were no significant differences in body weight and body fat among the high‐fat fed groups. High‐fat fed mice consumed less food than the controls (P < 0.05), however, there was no significant difference in caloric intake among all of the groups. High‐fat diets, with the exception of the fish oil diet, elevated plasma levels of insulin compared to the controls (P < 0.05) with no difference in plasma insulin between the control and the fish oil groups. Plasma concentrations of adiponectin were significantly elevated in the fish oil‐fed group compared to the control group (P < 0.05) or each of the other high‐fat fed groups (P < 0.05). We conclude that consumption of fish oil may affect adipokine profile in mice in a favorable manner compared to other types of dietary fats.