Abstract
Breast cancer (BC) is the second leading mortality cause due to poor survival rates compared to lung cancer all over the world. Recently, lifestyle increased obesity among the population globally. Since, the adipose tissues (AT) are the major contributor to the volume of the breast and adipocytes cells, which constitute AT are one of the major prominent cells play an effective role in cancer progression via releasing different mediators and adipokines. Thus, AT may display a crucial role in BC progression, especially in obese patients compared to non-obese patients, which characterized by increased AT. Interestingly, adipocytes are characterized by expressing caveolin-1 (Cav-1) protein. Cav-1 constitutes the lipid raft of caveola which contains different proteolytic enzymes inducing cancer metastasis. In this regard, the aim of the present study was to explore the level of expression of Cav-1 protein in the tissue specimen of 5 non-obese vs. 15 obese patients using immunohistochemistry (IHC) and immunoblotting techniques. Our finding demonstrates that thelevel ofCav-1expression was statistically significantly low in non-obese compared to obese BC patients (p < 0.05). Herein, our results revealed that the highest expression of Cav-1in obese patients compared to non-obese (control) patients can be considered as a biomarker for BC patients.
Highlights
Women with breast cancer (BC) remains the second lethal form of cancer disrupts the female's lives over the world after lung cancer (Torre, Bray, Siegel, & Ferlay, 2015; Yedjou et al, 2019)
The tumor grade analysis among obese patients revealed that 78.57% were classified as grade II (G2) and 21.43% were grade III (G3), while 100% classified as grade 2 (G2) in nonobese
In the present study, our data further demonstrated that the highest secreted adipokines are IL-6, IL-8, and MCP-1 and there is a high expression of Cav-1 protein level in adipose breast carcinoma tissues by adipocytes of obese vs. non-obese
Summary
The aim of the present study was to explore the level of expression of Cav-1 protein in the tissue specimen of 5 non-obese vs. 15 obese patients using immunohistochemistry (IHC) and immunoblotting techniques. The objective of this study was to determine the expression levels of Cav-1 protein in AT of non-obese vs. obese BC patients by IHC and immunoblotting
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