Abstract
Plasmodium falciparum-infected erythrocytes (pRBC) in the peripheral blood of children with severe malaria display a higher probability of binding to multiple cellular and circulating receptors compared with those in children with mild malaria. In addition to assessing rosette and giant rosette formation, A. Heddini et al. assessed binding of pRBC in 111 fresh clinical isolates to CD36, intercellular adhesion molecule 1, thrombospondin, heparin, blood group A and immunoglobulins [(2001) Infect. Immun. 69, 5849–5856]. These results support the concept that isolates that bind to multiple receptors are involved in the causation of severe malaria and that several ligand–receptor interactions work synergistically, thus leading to severe disease. SHK
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