Abstract
Cellular and membrane adhesion in biology is a highly complex and ubiquitous process, where specific and non-specific interactions mediate biological functions. Model systems such as liposomes can provide a means of testing biophysical hypotheses. Dip-pen nanolithography (DPN) is a promising method of printing lipid droplets onto solid surfaces at length scales relevant to biological cells, and can be carried out in parallel and with high throughput. Phospholipids are a particularly useful as inks for DPN because of their physicochemical properties as well as innate biofunctionality.(1-3) Here the dynamic adhesion properties of lipid multilayer structures fabricated by DPN is studied. Short-timescale kinetics of lipid spreading and other shape changes within the micro-and nanostructured lipid multilayers is studied. By forming the lipid multilayers into optical diffraction gratings, a label-free read out and biosensing mechanism is developed based on these shape changes within the fluid and adherent lipid multilayers.(4)
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