Abstract
Non-infectious uveitis (NIU) is an inflammatory eye disease initiated via CD4+ T-cell activation and transmigration, resulting in focal retinal tissue damage and visual acuity disturbance. Cell adhesion molecules (CAMs) are activated during the inflammatory process to facilitate the leukocyte recruitment cascade. Our review focused on CAM-targeted therapies in experimental autoimmune uveitis (EAU) and NIU. We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin) pathways. P-selectin and E-selectin are more involved specifically in uveitis related to vasculitis. These therapies have potential clinical applications for the development of a more personalized and specific treatment. Localized therapies are the future direction to avoid serious systemic side effects.
Highlights
Non-infectious uveitis (NIU) describes a broad disease spectrum involving inflammation in the pigmented middle layer of the eye driven by autoimmune and autoinflammatory pathways [1,2]
intercellular cell adhesion molecule-1 (ICAM-1) is constantly expressed on retinal pigment (RPE), and its experimental autoimmune uveitis (EAU) has been reported
Models,epithelium the expression leveland is upregulated after inflammation is induced most addressed Cell adhesion molecules (CAMs) are ICAM-1 its ligand (LFA-1; a β2-integrin)
Summary
Non-infectious uveitis (NIU) describes a broad disease spectrum involving inflammation in the pigmented middle layer of the eye (uvea) driven by autoimmune and autoinflammatory pathways [1,2]. NIU has a higher prevalence in people of working age, and a significant socioeconomical impact [3,4]. This intraocular inflammation is mediated via antigen-specific CD4+ T cells becoming activated, which proliferate centrally and migrate into the eye. During the steps of the leukocyte recruitment cascade, a distinct set of adhesion molecules is activated to fine-tune the process temporally and spatially [6,7]. Cell adhesion molecules (CAM) are glycoproteins expressed on the cell surface and include the integrin family, the immunoglobulin superfamily, selectins, and cadherins [8]. It was noticed that the involvement of integrins, selectins, and cadherins was mainly reported in uveitis [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
