Abstract
The aim of this study was to investigate blood neutrophil functional properties and the relationships to systemic inflammation in order to better understand a role of systemic inflammation for PH occurrence in COPD patients. Methods . This was a local open comparative study involving 30 patients with COPD (15 patients with PH and 15 patients without PH). The blood neutrophil functional properties (cell membrane stiffness and adhesion force) were measured using the atomic force microscopy. The power spectroscopy was used to quantitatively assess the adhesion force and neutrophil cell membrane stiffness (the Young's modulus). Results . Blood neutrophil and thrombocyte numbers, CRP and fibrinogen levels were significantly higher in patients with COPD + PH compared to COPD patients without PH. Relationships were found between systemic inflammation biomarkers and systolic pulmonary artery pressure. Conclusion . The results demonstrated that the membrane stiffness and the adhesion force were significantly increased in COPD patients with PH compared to controls and to COPD patients without PH. These neutrophil parameters were closely related to systemic inflammation.
Highlights
The results demonstrated that the membrane stiffness and the adhesion force were significantly increased in COPD patients with PH compared to controls and to COPD patients without PH
Garcia Rio F., Miravitlles M., Soriano J.B. Systemic inflammation in chronic obstructive pulmonary disease: a population based study
Summary
Жесткость мембраны нейтрофилов и биомаркеры системного воспаления у больных хронической обструктивной болезнью легких с легочной гипертензией. 1 – ГБОУ ВПО "Башкирский государственный медицинский университет" Минздрава России: 450000, Россия, Уфа, ул. 3; 2 – ГБОУ ВПО "Башкирский государственный университет", Центр микро и наномасштабной динамики дисперсных систем: 450076, Россия, Уфа, ул. 4. Методом атомно силовой микроскопии проведен анализ вязкоупругих свойств (силы адгезии и жесткости мембраны) нейтрофилов, изучены их взаимосвязи с биомаркерами системного воспаления (СВ) у больных хронической обструктивной болезнью легких(ХОБЛ) в зависимости от наличия легочной гипертензии (ЛГ). 1 – State Institution "Bashkir State Medical University": 3, Lenina ul., Ufa, 3450000, Bashkir Republic, Russia; 2 – State Institution "Bashkir State University", The Center of Nano and Microdynamics of Disperse Systems: 32, Z.Validi ul., Ufa, 450076, Bashkir Republic, Russia; 3 – Federal Institution "Pulmonology Research Institute", Federal Medical and Biological Agency of Russia: 32, build. 1 – State Institution "Bashkir State Medical University": 3, Lenina ul., Ufa, 3450000, Bashkir Republic, Russia; 2 – State Institution "Bashkir State University", The Center of Nano and Microdynamics of Disperse Systems: 32, Z.Validi ul., Ufa, 450076, Bashkir Republic, Russia; 3 – Federal Institution "Pulmonology Research Institute", Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya ul., Moscow, 105077, Russia
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