Abstract
Twelve of 17 strains ofEscherichia coli from patients with proven upper uninary tract infection (UT) were shown to adhere to kidney tissue from rabbits. In contrast, only two of nine strains ofE. coli from humans with lower urinary tract infections (LT) adhered to kidney tissue. In addition, the effect of mannose on adherence to rabbit kidney tissue correlated with the effect of mannose on agglutination of guinea pig or human erythrocytes. Adherent isolated had pili demonstrated by electron microscopic studies and were more hydrophobic than were nonadherent isolates. These studies provide evidence that the surface of the bacillis is important in initiation of infection of kidney tissue byE. coli.
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