Abstract
Allopurinol is the most commonly used medication to treat hyperuricaemia as a cause of gout. One of the challenging aspects of initiating allopurinol therapy is that treatment can precipitate flares, and can therefore do the opposite of what it is intended for—a situation that patients can understandably find confusing. To reduce the likelihood of flares, allopurinol needs to be started at a low dose and uptitrated; anti-inflammatory prophylaxis, such as colchicine, needs to be co-prescribed; and a treatment plan for managing flares should be given to the patient.
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