Abstract
Objective: To study adherence to treatment with atorvastatin at various doses for 48 weeks in patients with STEMI. Design and method: The study included 117 STEMI patients mean age 52.1 ± 8.4 years in the first 24–96 hours from the disease onset. In accordance with the lipid-lowering therapy, the patients were divided into two groups. The first group included 39 people taking atorvastatin 40 mg/day. The second group consisted of 78 patients who received atorvastatin 80 mg/day. On 7–9th day from the STEMIt, after 24 and 48 weeks of follow-up, treatment adherence was assessed using the Morisky-Green questionnaire. In addition, compliance was determined based on the number of dispensed and returned drugs. Results: After 48 weeks of follow-up, pharmacotherapy was continued in the 1st group of 30 people (76.9%), in the 2nd group - 73 (93.6%) patients (p = 0.008); 9 patients (23.1%) from group 1 and 5 people (6.4%) from group 2 (p = 0.008) independently discontinued treatment. After 48 weeks of follow-up, 17 patients (43.6%) in the 1st group were assigned to the number of compliant patients, and 39 people (50%) in the 2nd subgroup (p = 0.54). Ten patients (25.6%) in group 1 and 15 patients (19.2%) in group 2 (p = 0.39) turned out to be insufficiently adherent. There were 3 people not adhering to treatment in the 1st group (7.7%), in the 2nd group - 19 people (24.4%) (p = 0.03). In group 1, the mean score was initially 4 (4;4) points, after 24 weeks - 4 (3;4) points (p = 0.96), after 48 weeks - 4 (3;4) points (p = 0.87). In the group 2 - 4 (4;4) points, after 24 weeks - 4 (3;4) points (p = 0.99), after 48 weeks - 4 (2;4) points (p = 0.34). According to the number of issued and returned drugs, the average amount of drugs taken in group 1 was 91.8 (79;99)%, in the 2nd group - 96.9 (82.8; 100)% (p = 0.23). The correct drug intake (>80% compliance) in group 1 was observed in 21 patients (76.7%); in group 2 - 57 (78.1%). Conclusions: in STEMI patients, 48-week atorvastatin treatment was characterized by good adherence and did not depend on the dose of the drug taken
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