Abstract
The prevalence of ADHD, its neurological correlates, and the effect of ADHD on health-related quality of life in 203 children (mean age 11.8 years, SD 3.8) with severe epilepsy were evaluated at British Columbia Children's Hospital, Vancouver, Canada.
Highlights
The prevalence of ADHD, its neurological correlates, and the effect of ADHD on health-related quality of life in 203 children with severe epilepsy were evaluated at British Columbia Children's Hospital, Vancouver, Canada
Age of onset of seizures, epilepsy duration, and seizure frequency were not related to severity of inattention or hyperactivityimpulsivity
ADHD-Combined Inattentive/Hyperactive-Impulsive subtype (ADHD-C) was associated with earlier onset of seizures, generalized epilepsy, and more frequent seizure intractability, compared to ADHD-Inattentive subtype (ADHD-I)
Summary
The prevalence of ADHD, its neurological correlates, and the effect of ADHD on health-related quality of life in 203 children (mean age 11.8 years, SD 3.8) with severe epilepsy were evaluated at British Columbia Children's Hospital, Vancouver, Canada. Age of onset of seizures, epilepsy duration, and seizure frequency were not related to severity of inattention or hyperactivityimpulsivity. ADHD-I was associated with a greater frequency of localization-related epilepsy, and more frequent use of AEDs with cognitive side effects (benzodiazepines, topiramate, phenobarbital). Quality of life was impaired two-fold in children with severe epilepsy complicated by ADHD-I, and four-fold with ADHD-C comorbidity, when compared to non-ADHD/epilepsy patients.
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