Abstract
In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340–0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6.074; 95% CI, 1.426–25.870; p = 0.015) in CDH1 were associated with overall survival. Our data suggest that polymorphisms in ADH1B and CDH1 may be prognostic indicators in LC.
Highlights
Laryngeal cancer (LC) is a common type of malignant head and neck tumor, and the incidence is increasing yearly [1]
We investigated 37 single nucleotide polymorphisms (SNPs) in 27 genes that were previously associated with head and neck cancers to determine whether they were associated with the prognosis of laryngeal cancer (LC) patients
We evaluated the effects of 37 SNPs in 26 genes on the prognosis of 170 Han Chinese male LC patients
Summary
Laryngeal cancer (LC) is a common type of malignant head and neck tumor, and the incidence is increasing yearly [1]. While the majority of LC patients have a history of smoking and alcohol consumption [4], only a small percentage of individuals with similar histories eventually develop LC. This suggests that genetic susceptibility underlies LC [5]. Host genetic factors may influence the prognosis of cancer patients. Rare host genetic factors that influence the prognosis of advanced LC patients have been reported. We investigated 37 SNPs in 27 genes that were previously associated with head and neck cancers to determine whether they were associated with the prognosis of LC patients
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