Adequate Responses to an Acellular Pertussis Booster Vaccination in Children, Adolescents, and Young and Older Adults: A Collaborative Study in Finland, the Netherlands, and the United Kingdom

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Background: Pertussis can lead to serious disease and even death in infants. In addition older adults and patients with chronic diseases are more vulnerable to complications. In high-income countries, priming vaccination in infancy is usually undertaken using acellular pertussis vaccines. There is a significant between-country variation in the use of booster vaccinations which are administered at different ages and to different target populations. We investigated the effect of age on the response to acellular pertussis booster vaccination in three European countries. Methods: In total 379 participants, divided between four age groups - children (7-10y), adolescents (11-15y), young adults (20-34y), and older adults (60-70y) - received a pertussis toxoid, filamentous haemagglutinin, and pertactin containing booster vaccine. Serum IgG and IgA antibody concentrations to pertussis vaccine antigens at day 0, day 28, and one year were measured with a multiplex immunoassay. Findings: Participants from all four age groups showed high IgG antibodies to pertussis toxin at day 28. IgG antibody concentrations at 28 days and one year postvaccination were comparable between the age groups, but IgA concentrations showed an increase of antibody concentrations with age at all timepoints. Interpretation: Acellular pertussis booster vaccination induces comparable serological responses in older adults as younger age groups and could be considered for older adults in order to increase their protection. Trial Registration: The trial was registered at the EU Clinical Trial database (EudraCT number 2016-003678-42). Funding: PERISCOPE has received funding from the Innovative Medicines Initiative2 Joint Undertaking under grant agreement No 115910. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme, EFPIA and BMGF. Declaration of Interests: None of the authors received payment or service from a third part at any time, nor does anyone have a financial relationship with entities in the bio-medical arena. None of the authors have any patents relevant to the work. MVP is a member of the Portuguese National Immunisation Technical Advisory Group (Comissao Tecnica de Vacinacao da Direccao Geral de Saude). Ethics Approval Statement: The trial was approved by the Medical Research Ethics Committees United (MEC-U, NL60807.100.17-R17.039) in the Netherlands, the South Central - Hampshire B Research Ethics Committee (REC, 19/SC/0368) in the UK, and the MREC UTU (ETMK Dnro: 129/1800/2017) in Finland. Written informed consent was obtained from all adult participants, and parents or legal guardian of minors, at the start of the study.