Abstract
The aim of this study was to evaluate the adequacy of family history taking in epithelial ovarian cancer (EOC) patients and to identify factors that determine adequacy. Furthermore, the validity of family history taking was assessed by comparison with self-administered questionnaires. Medical records of all 1,112 EOC patients registered by the nation-wide cancer registry and diagnosed in eleven Dutch hospitals between 1996 and 2006 were reviewed. Adequate family history taking was defined as a written notification of the presence or absence of relatives with breast or ovarian cancer. Factors that were correlated with family history taking were identified using univariable and multivariable logistic regression. 147 patients filled in a postal questionnaire. An adequate family history was taken in 41% of all cases. Younger age, an academic hospital and having undergone surgery and/or chemotherapy were associated with adequate family history taking. The comparison with self-administered questionnaires showed a disagreement in 64% mainly due to missing data in medical records. Documentation on family history is either absent or inadequate in the medical records in the majority of EOC patients. These data urge for better uptake of hereditary cancer risk assessment. Different strategies for this assessment like improved family history taking and genetic testing in EOC patients should be explored.
Highlights
The aim of this study was to evaluate the adequacy of family history taking in epithelial ovarian cancer (EOC) patients and to identify factors that determine adequacy
Adequate family history taking was defined as a written notification of the presence or absence of relatives with breast or ovarian cancer
Univariable logistic regression analysis showed age, hospital type, year of diagnosis, menstrual state, breast cancer (BC) in the past, Karnofsky score, histology, having surgery or chemotherapy, recurrence, and inclusion in a trial, to be significantly correlated with adequacy of family history taking
Summary
The aim of this study was to evaluate the adequacy of family history taking in epithelial ovarian cancer (EOC) patients and to identify factors that determine adequacy. Documentation on family history is either absent or inadequate in the medical records in the majority of EOC patients These data urge for better uptake of hereditary cancer risk assessment. Different strategies for this assessment like improved family history taking and genetic testing in EOC patients should be explored. BSO is indicated in BRCA-carriers around the age of 40 It reduces the risk of ovarian cancer by up to 96% and halves the risk of breast cancer (BC) in pre-menopausal women [12,13,14,15]
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