Abstract
Adenylate cyclase was present in microsomal fractions of ventricular muscle. The enzyme in this fraction could be distinguished from activity in the easily sedimentable (plasma membrane fraction) on the basis of response to nonionic detergents, phospholipase A incubation and rate of activation by guanine nucleotide and epinephrine. The data suggest that a small percentage of adenylate cyclase in the heart resides within membranes of the sarcoplasmic reticulum. Adenylate cyclase in plasma membranes prepared from fast skeletal muscle was stimulated by guanine nucleotide (Gpp(NH)p) and catecholamines. On the basis of agonist and antagonist potency with respect to enzyme activation and catecholamine binding it is concluded that in skeletal muscle, adenylate cyclase is coupled to adrenergic receptors of the β2 type.
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