Abstract
Rauscher murine erythroleukemia cells undergo erythroid differentiation in response to the hormonal inducer erythropoietin and to synthetic inducers. Incubation of these cells with (−) isoproterenol or (−) epinephrine results in a 2–3-fold increase in cyclic AMP levels. This effect is completely blocked by propranolol, identifying the response as due to a β-adrenergic receptor·adenylate cyclase system. Experiments with [ 125I]iodohydroxybenzylpindolol demonstrate 1700 β-adrenergic receptors/cell with a K D of 320 pM. These results form the basis for further studies of the β-adrenergic receptor·adenylate cyclase complex during erythropoiesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
