Abstract
Abstract Adenyl cyclase activity in homogenates of thoracic and abdominal aorta from young and old rabbits was neither stimulated nor inhibited by isoprenaline, noradrenaline, 5-hydroxytryptamine, or histamine but was markedly increased by sodium fluoride. Sodium fluoride-stimulated adenyl cyclase activity was significantly higher in the abdominal than in the thoracic aorta. Neither the basal nor sodium fluoride-stimulated adenyl cyclase activity of thoracic aorta changed with increasing age of the aorta. On the other hand, the abdominal aorta showed an increase in sodium fluoride-stimulated activity but no change in basal activity with increasing age. After the ATP pool of intact thoracic aorta was prelabelled with [14C]-adenine, isoprenaline did not enhance the formation of labelled cyclic AMP in intact aortic strips. Based on these data no correlation could be made between adenyl cyclase activity and the β-receptor activity of this tissue.
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