Abstract
Adenoviruses are frequent causes of respiratory disease in the US military population. A successful immunization program against adenovirus types 4 and 7 was terminated in 1999. Review of records in the Mortality Surveillance Division, Armed Forces Medical Examiner System, identified 8 deaths attributed to adenovirus infections in service members during 1999-2010.
Highlights
Adenoviruses are frequent causes of respiratory disease in the US military population
Adenoviral respiratory disease has been recognized as a frequent cause of illness in the US active duty military population for >5 decades, at basic training installations [1,2,3,4,5]
After the only manufacturer of the adenovirus vaccines ended production, adenoviral respiratory disease resurged after the phased cessation and eventual termination of adenovirus vaccinations during 1996–1999 [3,4,8]
Summary
Adenoviruses are frequent causes of respiratory disease in the US military population. Review of records in the Mortality Surveillance Division, Armed Forces Medical Examiner System, identified 8 deaths attributed to adenovirus infections in service members during 1999–2010. 8 were attributed to adenovirus respiratory disease as the sole contributor or a co-contributor to death after review of available records by an AFMES pathologist (J.A.C.). For these 8 patients, the mean age was 21.3 years (range 18–32 years). Patient A had a respiratory infection with adenovirus type 14, which was confirmed by testing of a nasal wash specimen Several days later he was hospitalized and required care for multilobar pneumonia and acute respiratory distress syndrome. Demographic characteristics and adenovirus type for US military members who died of adenovirus-associated infections, 1998–
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