Abstract
Malignant melanoma requires precise resection in order to avoid metastatic recurrence. We report here that the telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401 could label malignant melanoma with GFP in situ in orthotopic mouse models. OBP-401-based fluorescence-guided surgery (FGS) resulted in the complete resection of malignant melanoma in the orthotopic models, where conventional bright-light surgery (BLS) could not. High-dose administration of OBP-401 enabled FGS without residual cancer cells or recurrence, due to its dual effect of cancer-cell labeling with GFP and killing.
Highlights
Despite recent advances, the current therapeutic approaches in melanoma are not satisfactory and intensive research in this area is still required [1].Cancer surgery requires precise identification of tumor margins
In an intraperitoneal nude mouse model of disseminated human colon cancer, fluorescence-guided surgery (FGS) enabled resection of tumor nodules labeled with green fluorescent protein (GFP) by OBP-401 [4]
We previously developed a curative strategy for FGS of Glioblastoma multiforme (GBM) using high-dose OBP-401 to selectively label GBM with GFP
Summary
The current therapeutic approaches in melanoma are not satisfactory and intensive research in this area is still required [1].Cancer surgery requires precise identification of tumor margins. OBP-401-based fluorescence-guided surgery (FGS) resulted in the complete resection of malignant melanoma in the orthotopic models, where conventional bright-light surgery (BLS) could not. High-dose administration of OBP-401 enabled FGS without residual cancer cells or recurrence, due to its dual effect of cancer-cell labeling with GFP and killing. In an intraperitoneal nude mouse model of disseminated human colon cancer, fluorescence-guided surgery (FGS) enabled resection of tumor nodules labeled with GFP by OBP-401 [4].
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