Abstract
Objectives: On molecular level Marfan patients show lysis of aortic elastin layers caused by the proteolytic activity of matrix-metalloproteinases (MMP). Overexpression of Tissue Inhibitor of Matrix Metalloproteinases-1 (TIMP-1) may reduce elastolysis of the media and stabilize the vascular wall. In this study we present the first adenoviral mediated gene transfer of TIMP-1 in Fibrillin-1 deficient mice (mgR/mgR).
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