Adenosquamous carcinoma of the cervical oesophagus in a dog

Francisca Maria Sousa Barbosa,Ricardo Barbosa Lucena,Tolentino Lira Alcântra,Natanael Félix Silva Filho,Glaucia Denise Kommers,Alex Dos Santos,Gisele Castro Menezes

doi:10.1590/0103-8478cr20190788

Abstract

ABSTRACT: A 9-year-old male Shih Tzu dog presented with a mass on the ventral region of the neck and developed ptyalism. Radiographs revealed a radiodense nodule located in the mid-third of the oesophagus compressing the trachea. Preoperative cytology showed large neoplastic cells with abundant vacuolated cytoplasm arranged in clusters. The nodule was removed by oesophagectomy and submitted for histopathology. Microscopically, the oesophageal mass was multilobulated and unencapsulated. It had a mixed cellular growth pattern with areas showing squamous and glandular differentiation. The squamous component of the tumor was formed by solid strands of neoplastic epithelial cells; many neoplastic cells had undergone central keratinization and sometimes formed keratin pearls. The deeper adenocarcinomatous portion of the tumor consisted of tubules filled with slightly basophilic mucinous material. Histological and immunohistochemical examination confirmed the diagnosis of primary adenosquamous carcinoma (ASC) of the esophagus. This is the first report of primary ASC of the cervical oesophagus in a dog.

Highlights

Carcinoma adenoescamoso do esôfago cervical em um cão RESUMO: Um cão Shih Tzu de nove anos de idade apresentou uma massa na região ventral do pescoço e desenvolveu ptialismo
squamous cell carcinoma (SCC) of the oesophagus are malignant tumors originating from the oesophageal stratified squamous epithelium, and occur infrequently in animals (UZAL et al, 2016), with the exception of oesophageal SSCs that affect cattle grazing on pastures invaded by Pteridium spp. (LUCENA et al, 2011)
The squamous component was formed by solid strands of neoplastic epithelial cells that extended from the epithelial lining of the oesophageal mucosa and invaded the underlying submucosa

Summary

Introduction

Carcinoma adenoescamoso do esôfago cervical em um cão RESUMO: Um cão Shih Tzu de nove anos de idade apresentou uma massa na região ventral do pescoço e desenvolveu ptialismo. Squamous cell carcinomas (SCCs), fibrosarcomas, osteosarcomas, and leiomyomas are the more common types of primary esophageal tumor of dogs (MCCAW et al, 1980, RANEN et al, 2004a, RANEN et al, 2004b). There is only one case report of this type of tumor in a dog There are no published reports of adenosquamous carcinoma of the cervical oesophagus in dogs.

Results

Conclusion