Abstract
Carbon dioxide induces a rapid dilation of cerebral arterioles, enabling local blood flow to match increasing metabolic requirements of tissue. Amongst the vasodilatory substances released by cortical tissue in response to CO 2 are adenosine and nitric oxide. Here we report that selective adenosine A 2A receptor antagonists, applied topically using a rat cortical window technique, significantly depressed the CO 2-evoked increase in arteriolar diameter, measured using video microscopy, as well as attenuating the CO 2 and pH reactivity of the cortical arterioles. Two non-selective inhibitors of nitric oxide synthase also significantly depressed the hypercapnia-evoked increase in arteriolar diameter.
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