AdenosineN(1)-Oxide Complexes with Divalent 3d Metal Perchlorates

Abstract

Abstract Complexes of adenosine N(1)-oxide (LH), 1, with divalent 3d metal perchlorates (M α Mn, Fe, Co, Ni, Cu, Zn) were synthesized by refluxing 2:1 molar mixtures of ligand and hydrated metal salt in triethyl orthoformatc-cthanol. The new complexes isolated are of the ML(LH)CIO4 (M α Mn, Cu), ML(LH)ClO4. EtOH (M α Fe, Co, Zn) and NiL(LH)ClO4.2EtOH types, containing one neutral LH and one anionic L- ligand deprotonated at the exocyclic NH2 group and replacing one ClO4 - anion. Characterization studies suggest that LH acts as bridging bidentate (O1,N7-bound) and L- as a bidentate chelator binding via O1,N6. The complexes appear to be linear chainlike polymers with a -(-M-LH-)-n single-bridged backbone and a chelating L- ligand per metal ion. The alcohol-free Mn(II) and Cu(II) complexes are distorted tetrahedral with ionic perchlorate, while the remaining complexes are hexacoordi-nated with either two additional EtOH ligands and ionic perchlorate (M α Ni) or one EtOH and one -OClO3 ligand (M α Fc, Co, Zn)...