Adenosine uptake and metabolism in human endothelial cells.

Abstract

The handling of adenosine by the endothelium is crucial for the effects of this nucleoside in the vascular system. Strategic location of endothelial cells at the vessel wall border indicate its important role in the turnover of adenosine. High endothelial activity of ecto 5’nucleotidase1 implies predominant role in the extracellular formation of adenosine from secreted nucleotides. However, the capacity to release intracellularly produced adenosine, phosphorylation of extracellular adenosine and to some extent adenosine transit between interstitial and intravascular space depend on the membrane transport capacity in this type of cells.