Adenosine triphosphate utilization by “young” and “old” red cells

Abstract

“Young” red cells lose adenosine triphosphate more rapidly than “old” cells during incubation in the absence of glucose. Comparable findings with 2,3-diphosphoglycerate suggest that this precursor cannot account for the differential loss of adenosine triphosphate in cells of different ages. Studies with a cardiac glycoside indicate that the difference in adenosine triphosphate loss between young and old cells is ouabain resistant.