Abstract
Adenosine, an endogenous nucleoside, exertsmodulating effects in many cellular systems. Four distinct subtypes of adenosine receptors (A1, A2A, A2B and A3) belonging to the G-protein-coupled receptor family have been classified according to their ability to regulate adenylate cyclase activity [1]. Adenosine can provoke bronchoconstriction when inhaled by asthmatic individuals but not in normal subjects [2] indirectly through mast cells [3]. While a predominantly excitatory action of adenosine on mast cell activation was confirmed in rodents, less conclusive results were obtained in humans [4, 5]. The aim of our study is to compare the effects of adenosine and adenosine receptor agonists on basal and anti-IgE induced histamine release from rat and human mast cells.
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