Abstract
5'-N-ethylcarboxamide (NECA) > 2-chloroadenosine (2-C1A)> adenosine (A) > (−)-N6-(R-phenylisopropyl)-adenosine {(−)-R-PIA}> (+)-S-PIA, in μ M concentrations, inhibited the release of histamine and immunoreactive leukotriene C4 (LTC4) from human basophils challenged with anti-IgE or antigen. The effect of NECA, 2-C1A and A was potentiated by dipyridamole and inhibited by low concentrations of theophylline (T). In contrast, NECA, 2-C1A, A and (−)-R-PIA, in μ M concentrations, enhanced the release of both histamine and LTC4 from mast cells purified from human lung. The effect of A and its analogs was not blocked by dipyridamole and partially inhibited by T. These results support the hypothesis that adenosine and its analogs produce distinct biological effect in the modulation of mediator release from human basophils and lung mast cells.
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